FDA Approves EVOLENCE®, a New Generation Collagen-Based Facial Filler

“EVOLENCE^® represents a new generation of facial fillers, an innovative structural agent providing beautiful, immediate results by replacing the collagen lost with long-lasting, naturally sourced collagen,” said Annie Heremans, M.D., Ph.D., Vice President, responsible for the Company’s research and development of the Medical and Aesthetic Dermatology franchises. “We are pleased to enter the U.S. aesthetic space with a differentiated dermal filler designed for optimal patient outcomes. Given our rich heritage in skin care and commitment to science, we anticipate EVOLENCE^® will be a welcome addition to current aesthetic treatment options.”

EVOLENCE^® will be introduced throughout the second half of 2008, in coordination with physician training, to ensure optimal patient satisfaction and outcomes.

EVOLENCE^® represents a breakthrough in aesthetics. As one of nature’s most fundamental and abundant building blocks, collagen comprises up to 80% of the dermis and it helps maintain skin strength, structure and support. Collagen naturally breaks down as a person ages, leading to the appearance of wrinkles, lines and folds.

EVOLENCE^® is an advanced collagen-based structural dermal filler that provides long-lasting treatment of moderate to deep facial wrinkles folds, such as nasolabial folds. The results of treatment with EVOLENCE^® are immediate, with little to no downtime post-treatment and clinically proven to last through six months. Additional data for 12-month duration approval is being filed with the FDA.

This new generation collagen filler is intended for injection into the mid-to-deep dermis for the correction of moderate to deep facial wrinkles and folds, such as nasolabial folds. The most common side effects of EVOLENCE^® injections are usually injection-site related and include mild swelling, redness, and pain. Other rare side effects include the development of small areas of firmness under the skin at the treated sites that may be noticed when the areas are pressed upon.